POLYPEPTIDES

摘要

Novel polypeptides of the formula R1-Arg-R2-Phe-Phe-R3 wherein R1 is hydrogen, or a basic or neutral amino acid residue, R2 is a neutral amino acid residue and R3 is NH2, Tyr-NH2, a residue of tyrosyl peptides consisting of 1 to 5 amino acid residues or amides of the tyrosyl peptides, provided that when R1 is hydrogen, R2 is Pro, are effectively used for treatment of insufficiency of carbohydrate metabolism and of lipid metabolism, especially for the treatment of diabetes by not only parenteral administration but also oral administration.