| 摘要 |
NEW MATERIAL:A pyrrole derivative of formulaI: (R4, R2, R3 and R4 are H, lower alkyl, phenyl, or pyridyl groups; R5, R6 and R7 are H, lower alkyl, phenyl, or nitro groups) and its acid addition salt. EXAMPLE:2,5-dimethyl-1-guanidino-pyrrole. USE:Oncostatic drugs and hypotensives. PROCESS:One mole of an aminoguanidine derivative of formula II or its acid addition salt is reacted with 1-5mol, preferably 1-1.2mol of a 1,4-diketone derivative of formula III in a solvent, e.g. benzene, toluence, diethyl ether, etc. at 0-200 deg.C, preferably room temperature to 120 deg.C to give the pyrrole derivative of formulaI. |
