| 摘要 |
<p>Dipeptide compounds derived from histidyl-proline, namely acyl derivatives of histidyl prolinamide such as orotyl-L-histidyl-L-prolinamide, L-2-oxo-imidazolidine-4-carbonyl-L-histidyl-L-prolinamide, L-5-oxo-thiomorpholine-3-carbonyl-L-histidyl-L-prolinamide and others (and salts of such compounds with pharmaceutically acceptable acids) can be used as psycho-stimulating or anti-depressive agents, respectively. They may be produced for instance by reacting histidyl prolinamide with appropriate acids in presence of an agent, which is able to split off water or with a functional derivative of such an acid. A further preferred process for the preparation of an orotyl-histidyl-prolinamide consists in hydrogenolytic dehalogenation of a 5-chloro- or 5-bromo-histidyl-prolin amide obtained by acylating histidyl prolinamide with 5-chloro- or 5-bromo orotic acid or a functional derivative thereof.</p> |
