9-Thia-12-azaprostanoic acid derivatives and compositions containing them.

摘要

This invention provides novel interphenylene 9-this-11-oxo-12-azaprostanoic acid compounds and salts and other derivatives thereof. These compounds are exceptionally potent renal vasodilators and antihypertensives which are active when administered orally but which have a more specific type of bilogical activity than that of many of the natural prostaglandins and their synthetic analogs or derivatives. They are therefore made into pharmaceutical compositions. …The compounds have the formula: …… where R is caboxy or a carboxy ester or amide. A is a monocyclic ring, n is 3 or 4; m is 0, 1 or 2; R<1> is hydrogen, deuterium, or methyl, Z ic a C2-3 chain, R<2> is hydrogen or alkanoyl, R<3> is hydrogen or alkyl and R<4> is an optionally substituted aliphatic hydrocarbon radical or R<3> and R<4> form a ring. Certain of the above definitions are broader than those in the specification.