| 摘要 |
Pharmaceutically active compounds of the formula I <IMAGE> and non-toxic salts thereof, in which n is an integer from 5 to 12, are prepared. This entails a corresponding 8-halo-cyclic-adenosine monophosphate or an inorganic or organic salt thereof being reacted with an alkali metal salt of a linear alkyl mercaptan of the general formula CH3(CH2)nSH in which n is an integer from 5 to 12, preferably in the presence of an alcohol as solvent. The prepared compounds have excellent biological and pharmacological activities, especially as PDE inhibitors and display increased membrane permeability.
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