发明名称 |
BETA-LACTAM COMPOUNDS, PREPARATION AND USE |
摘要 |
The compounds of the formula (I): <CHEM> wherein X represents a moiety of the sub-formula (a) or (b): <CHEM> have been found to be beta -lactamase inhibitors which may be used in pharmaceutical compositions to enhance the effectiveness of penicillins or cephalosporins. The diene of the formula (I) may be produced by the decarboxylation of clavulanic acid or a derivative thereof and the monoene of the formula (I) may be produced by the 1,4 addition of hydrogen to the diene of the formula (I). The diene is thus also useful as a chemical intermediate and other such uses are demonstrated.
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申请公布号 |
US4145430(A) |
申请公布日期 |
1979.03.20 |
申请号 |
US19780921738 |
申请日期 |
1978.07.03 |
申请人 |
BEECHAM GROUP LIMITED |
发明人 |
HUNT, ERIC |
分类号 |
A61K31/42;A61P31/04;C07D498/14;C07D503/00;(IPC1-7):C07D498/04 |
主分类号 |
A61K31/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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