摘要 |
A process for producing 4-aryl- quinazolin-2(1H)-ones comprises dehydrating a corresponding 4-aryl- 5,6,7,8-tetrahydro-2(1H)- quinazolinone with sulphur in an inert organic solvent, in the presence of an inorganic metal oxide, hydroxide or salt (other than of magnesium, aluminium or an alkali metal), which forms a metal sulphide under the reaction conditions. The products are known as anti- inflammatory agents. |