发明名称 |
WERKWIJZE VOOR HET BEREIDEN VAN OPLOSSINGEN OF SUSPEN- SIES VAN LIPOSOMEN IN WATERIGE MEDIA. |
摘要 |
A process for the preparation of a solution or suspension of liposomes in an aqueous medium comprising the steps of dispersing a first aqueous liquid in an essentially water-insoluble solvent in the presence of a compound of the formula XY wherein X is a hydrophilic lipophobic group and Y is a lipophilic hydrophobic group to form a dispersion of liposome precursors in the solvent, the precursors consisting of small vesicles of the first aqueous liquid surrounded by a monomolecular film of compound XY, emulsifying the liposome precursors in a second aqueous medium in the presence of a compound of the formula ZW wherein Z is a hydrophilic group and W is a hydrophobic group to thereby form a solution or suspension of liposomes in the second aqueous medium, said liposomes consisting of the first aqueous liquid surrounded by a bimolecular film of the structure XY-WZ and removing the water-insoluble solvent prior to after said emulsification. |
申请公布号 |
NL7808167(A) |
申请公布日期 |
1979.02.07 |
申请号 |
NL19780008167 |
申请日期 |
1978.08.03 |
申请人 |
BATTELLE MEMORIAL INSTITUTE TE CAROUGE, ZWITSERLAND. |
发明人 |
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分类号 |
B01J13/12;A61K9/10;A61K9/127;A61K9/50;B01J13/02;(IPC1-7):01J13/02;61K9/00 |
主分类号 |
B01J13/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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