| 摘要 |
Compounds of the formula <IMAGE> (I) and salts and esters thereof wherein R1 is hydrogen, alkyl of 1 to 4 carbon atoms, phenyl, alkenyl of 2 to 4 carbon atoms, alkynyl of 2 to 4 carbon atoms, acyl of 1 to 4 carbon atoms, a carboxylic acid group or ester thereof of 1 to 7 carbon atoms, or alkyl of 1 to 4 carbon atoms substituted by 1 or 2 halogen atoms, hydroxyl, substituted hydroxyl, amino, protected amino, substituted thio of 1 to 7 carbon atoms, substituted sulphinyl of 1 to 7 carbon atoms, substituted sulphonyl of 1 to 7 carbon atoms, or by a carboxylic acid group or ester thereof of 1 to 7 carbon atoms; R2 is hydrogen or alkyl of 1 to 4 carbon atoms, or is joined to R1 to form a cycloalkyl group of 3 to 6 carbon atoms; R3 is hydrogen, chlorine or bromine; and R4 is hydrogen, halogen, azido or amino; provided that when R4 is azido, R3 is hydrogen and R1 is methyl, R2 is not methyl, and that when R2 +L, R3 and R4 are hydrogen and R1 is hydroxyethyl or an acyl derivative thereof, the compound does not have the (2R, 3S, 5R) stereochemistry; inhibit certain beta -lactamate enzymes and are useful in antiseptic and disinfectant solutions.
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