摘要 |
Compounds of the formula <IMAGE> wherein (A) WHEN THE AMINO-SUBSTITUENT IS IN THE P-POSITION WITH RESPECT TO THE CARBONYL GROUP, R1 is chlorine in the o-position with respect to the carbonyl group, R2 is hydrogen, and R3 is ethylamino, cyclopentylamino, cyclohexylamino, cycloheptylamino, N-methyl-cyclohexylamino, benzylamino or 1-ethyl-pyrrolidyl-(2)-aminomethyl, or (B) WHEN THE AMINO-SUBSTITUENT IS IN THE O-, M- OR P-POSITION WITH RESPECT TO THE CARBONYL GROUP, R1 is hydrogen, chlorine or bromine, R2 is trifluoromethyl, nitro or, when R4 is 1-(alkyl of 1 to 3 carbon atoms)-pyrrolidyl or 1-(alkyl of 1 to 3 carbon atoms)-piperidyl, also fluorine, chlorine, bromine or methyl, R3 is (alkyl of 1 to 5 carbon atoms)-amino, (cycloalkyl of 3 to 7 carbon atoms)-amino, benzylamino, quinuclidinyl-amino or -NH-(CH2)n-R4 where R4 is pyridyl, 1-(alkyl of 1 to 3 carbon atoms)-pyrrolidyl, 1-(alkyl of 1 to 3 carbon atoms)-piperidyl or, when n is 2 or 3, also imidazolonyl, pyrrolidino, piperidino or morpholino, and N IS 0, 1, 2 OR 3, AND NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF; THE COMPOUNDS AS WELL AS THEIR SALTS ARE USEFUL AS ANXIOLYTICS, ANTICONVULSIVES, ANTIEMETICS AND ANTIULCEROGENICS. |
申请人 |
DR. KARL THOMAE GMBH,DE |
发明人 |
KRUEGER,GERD,DE;KECK,JOHANNES,DE;PIEPER,HELMUT,DE;ZIEGLER,HARALD,DE;NOLL,KLAUS R.,DE;BALLHAUSE,HELMUT,DE;KAEHLING,JOACHIM,DE |