发明名称 NOVEL 11*33*3*4*55TRIMETHOXYPHENOXY**22 HYDROXYYPROPYL**44ARYLLPIPERAZINE DERIVATIVE PROCESS FOR PREPARING SAME AND MEDICINE CONTAINING SAME
摘要 The novel compounds correspond to the formula I, in which the substituents have the meaning given in Patent Claim 1. These compounds are prepared by reaction of a compound of the formula II with a compound of the formula III, Y and Z in each case being different and either denoting hydrogen or the group -CH2-CH(OR1)-CH2-V and V being chlorine, bromine or iodine, or, if R1 is hydrogen, can also form the ethylene oxide ring together with this hydroxyl group. If appropriate, one or two nitro groups in a compound of the formula I obtained can be reduced to amino groups and/or the compounds obtained can be acylated with an acid or an acid derivative corresponding to the radical R1. The compounds obtained can be converted into their acid addition salts. The novel compounds are pharmacodynamically active and are suitable as an active component in medicaments. <IMAGE>
申请公布号 JPS53130682(A) 申请公布日期 1978.11.14
申请号 JP19780039626 申请日期 1978.04.04
申请人 DEGUSSA 发明人 AKUSERU KUREEMAN;URAJIMIIRU YAKOFUREFU;KURAUSU TEIIMERU;YURUGEN ENGERU
分类号 C07D295/08;A61K31/495;A61K31/496;A61P25/18;A61P25/20;C07D213/74;C07D213/80;C07D295/033;C07D295/088;C07D295/092;C07D295/135;C07D303/24;C07D307/68;C07D333/38 主分类号 C07D295/08
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