发明名称 |
WERKWIJZE VOOR DE BEREIDING VAN PYRROLIDINE- VERBINDINGEN. |
摘要 |
Pyrrolidine derivatives of the formula <IMAGE> (I) are prepared from gamma -amino- beta -hydroxybutyric acid which, after reaction with a silylating agent, is reacted, in the presence of an acid acceptor, with a halogen derivative of an ester of an aliphatic acid and then cyclized to give the corresponding N-alkoxy-carbonylalkyl derivative which is converted into the corresponding amide by treatment with ammonia or with a mono- or di-substituted amine. The compounds produced by the present invention improve learning memory and display a protecting effect against the E.E.G. consequence of an overdose of barbituates and against the reduced performance following brain damage (e.g. cerebral edema). |
申请公布号 |
NL7801501(A) |
申请公布日期 |
1978.08.15 |
申请号 |
NL19780001501 |
申请日期 |
1978.02.09 |
申请人 |
I.S.F. SOCIETA PER AZIONI TE TREZZANO SUL NAVIGLIO, ITALIE. |
发明人 |
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分类号 |
C07D207/277;A61K31/40;A61K31/4015;A61P25/00;C07D207/26;C07D207/273;(IPC1-7):07D207/26 |
主分类号 |
C07D207/277 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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