| 摘要 |
Novel and biologically active 11 beta -substituted steroids of the oestrane series are disclosed having the formula <IMAGE> (I) wherein (a) R1 is O or ( alpha Y)( beta Z), wherein Y is selected from the group consisting of H, unsaturated aliphatic hydrocarbons of two to about four carbon atoms, saturated aliphatic hydrocarbons of about one to four carbon atoms, and Z is a free, esterified, or etherified hydroxy group; (b) R2 is H and R3 is H or CH3; in the alternative, R2 and R3 together constitute a carbon-carbon bond; and (c) ring A has the structure <IMAGE> wherein R4 in compound (II) is a free, esterified, or etherified hydroxyl group, and R5 in compound (III) is O or is two hydrogens. The new steroids possess oestrogenic, antioestrogenic, progestational, ovulation-inhibiting, uterotropic, androgenic, and anabolic properties for therapeutic administration. Administration may be accomplished via pharmaceutically acceptable compositions containing these compounds in a parenteral, oral or enternal manner (for example, liquid presentations as solutions, suspensions, emulsions, ointments, pastes and solid pharmaceutical presentations such as tablets, pills, capsules and dragees) to take advantage of the recited properties. |
