| 摘要 |
<p>Peptides (6-12 amino acids) and their salts, useful in allergy desensitization compositions, particularly vaccines, have the formula X-R-R1-R2-R3-Y where R is optional and, if present, is a group resistant to enzyme hydrolysis; R1 is a basic amino acid residue optionally linked to basic and/or neutral nonhydrophobic amino acid residues; R2 is one or more neutral nonhydrophobic amino acid residues; R3 is one or more hydrophobic amino acid residues optionally linked to neutral nonhydrophobic amino acid residues; X is hydrogen or an N-protecting group; and Y is hydroxyl or a C-terminal protecting group. Examples are: Lys Thr Lys Gly Ser Gly Phe Phe OCH3 Arg Lys Thr Lys Gly Ser Gly Phe Phe OCH3 Lys Thr Lys Gly Ser Gly Phe Phe Val Phe OCH3 Lys Thr Lys Gly Ser Gly Phe Phe Val Phe OH Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe OCH3 Lys Thr Lys Gly Ser Gly Phe Phe OH</p> |
