| 摘要 |
<p>The invention relates to compounds of the general formula: R' ¦ N-R4 N ANGLE R5 ¦ ¦N-N ANGLE R3¦ R3''R6 I in which one double bond is present between the carbon atom of the guanidine moiety and one of the adjacent nitrogen atoms and R0 stands for hydrogen, halogen, hydroxy, alkoxy or alkyl (1 to 6 C), R1, R2 for halogen, hydroxy, alkyl (1 to 4 C) or alkoxy (1 to 4 C), R3, R3', R3'' for hydrogen or alkyl (1 to 4 C) on the understanding that one of the substituents R3, R3' or R3'' is absent because of the presence of the double bond, R4 for hydrogen, alkyl (1-4 C), hydroxy, alkoxy (1-4 C) or amino optionally substituted with one or two alkyl (1 to 4 C) groups, R5, R6 for hydrogen, alkyl (1-6 C), acyl or R5 + R6 together represent an alkylidene, cyclic alklidene or aralkylidene group, AS WELL AS THE ACID ADDITION SALTS THEREOF, PROVIDED THAT, IF R4 stands for methyl and R0, R3, R3'', R5 and R6 for hydrogen, R1 and R2 may not represent methyl simultaneously, having a strong and long-acting anti-hypertensive activity.</p> |
