4-N-acylfortimicin B derivatives and the chemical conversion of fortimicin B to fortimicin A

摘要

This invention provides 4-N-acylfortimicin B derivatives of the structure <IMAGE> wherein R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, or substituted aminoacyl of the formula <IMAGE> where R1 is an acyl radical derived from an amino acid or a short peptide, and the pharmaceutically acceptable salts thereof.