摘要 |
<p>The subject compound, otherwise known as Fipexidum hydrochloride, is obtained by reacting the chloride of p-chlorophenoxyacetic acid with 1,4-bis-piperonylpiperazine, preferably in benzene solution under reflux conditions in the presence of a base such as sodium bicarbonate. The advantages of the process are low cost and high overall conversion due to easy recovery and recycle of relevant substances.</p> |