| 摘要 |
Compounds of the general formula I: <IMAGE> (I) in which R1 represents cycloalkyl, aralkyl, heterocyclic aryl, or substituted phenyl, in which the substituents on the phenyl group are one or more of the following groups, that is halogen, hydroxy, alkoxy (C1-C4), alkyl (C1-C4), nitro, dialkylamino or methylenedioxy; R2 represents a hydrogen atom, or together with the group R1 and the adjacent carbon atom represents a cycloalkyl group with 3 to 7 carbon atoms inclusive; R3 represents a group R5CO-, or R5CH(OH)- in which R5 is methyl or ethyl; R4 is an alkyl group (C1-C6) or a phenyl group; and in which where R4 is alkyl, R3 and R4 may be linked together to produce a 5-, 6- or 7-membered spirocyclic system with the adjacent carbon atom of the dioxan ring; and where the compounds contain hydroxyl groups, esters of such compounds; and where the compounds contain basic centers, non-toxic phrmaceutically acceptable salts with organic or inorganic acids. Pharmaceutical compositions comprising the specified compounds and other related compounds. Processes for the production of the compounds. The compounds have utility as analgetics.
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