Process of performing cyclization reactions using benzyl or pyridylamino malonic acid derivatives

摘要

Process of producing a naphthyridine or quinoline compound of the formula: <IMAGE> (II) wherein R2, R3, R4, and R6 can be alkyl, and R1 is nitrogen or CH. The corresponding pyridyl- or phenylaminomethylenemalonic acid diester is cyclized to yield said compound and an alcohol. The malonic acid diester at below reaction temperature is added to a solvent, e.g., diphenyl benzene, at above reaction temperature in proportion so that the mixture attains reaction temperature. Good yields at high throughputs are achieved.