PROCESS FOR PREPARING 8- AND/OR 9-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-2-BENZAZEPINE DERIVATIVES

摘要

This invention concerns a process for preparing 2-benzazepine compounds which inhibit the enzyme phenylethanolamine N-methyltransferase and show activity in reducing anxiety. The compounds produced have substituents in the 8- and/or 9-positions, and optionally substituents in the 1- and 2-positions. The compounds are prepared by debenzylating an appropriately substituted N-benzyl 2-benzazepine with optional acylation and reduction, or with optional ozidation and alkylation of the debenzylated product to introduce 2- and 1-position substituents, respectively. Acid addition salts of the compounds are also prepared.