VACCINES AND IMMUINOASSAYS FOR ACQUIRED IMMUNE DEFICIENCY SYNDROME

摘要

Recombinant viruses which direct the expression of peptides or proteins related to epitopes of LAV/HTLV III, the etiological agent of Lymphadenopathy Syndrome and Acquired Immune Deficiency Syndrome. These viruses can be formulated as viral vaccines or in multivalent vaccines that protect against LAV/HTLV III infection. Antigenic peptides and proteins related to epitopes of LAV/HTLV III are also described. These can be prepared using recombinant DNA techniques or by chemical synthesis and can be used as immunogens in subunit vaccines or as antigens in diagnostic immunoassays.