| 摘要 |
d1- and 8R-9-fluoro-11,15 alpha -dihydroxyprosta-5-cis,13-trans-dienoic acid, d1- and 8R-9-fluoro-11,15 alpha -dihydroxy-15 beta -methyl-prosta-5-cis,13-trans-dienoic acid and d1- and 8R-9-fluoro-11,15 beta -dihydroxy-15 alpha -methylprosta-5-cis,13-trans-dienoic acid, the pharmaceutically acceptable, nontoxic lower alkyl esters and salts thereof and process for the production of such compounds. 8R-9 beta -fluoro-11 alpha ,15 alpha -dihydroxyprosta-5-cis,13-trans-dienoic acid is a representative compound of the class. These compounds possess prostaglandin-like activities and thus are useful in the treatment of mammals where prostaglandins are indicated. They are particularly useful as luteolytic agents in female mammals and as bronchodilators. |
