MURAMYLDIPEPTIDDERIVAT OCH FORFARANDE FOR FRAMSTELLNING DERAV

摘要

Muramyldipeptide derivatives of the formula: wherein Y represents a mycoloyl group or a synthetic higher acyl group having total carbon number of C30-C90 and having at least a branched chain of long alkyl group on the alpha -position thereof, Q represents an -L-alanyl-D-isoglutamine group, a -glycyl-D-isoglutamine group or an -L-seryl-D-isoglutamine group; SALTS OF SUCH DERIVATIVES; THE METHOD OF PREPARING SUCH DERIVATIVES AND THEIR SALTS; THE DERIVATIVES AND THEIR SALTS HAVING POTENT IMMUNOADJUVANT ACTIVITIES AND ANTITUMOR ACTIVITY AND BEING APPLICABLE AS THE AGENT FOR THE IMMUNOTHERAPY OF CANCER FOR HUMANS AND ANIMALS.