发明名称 |
PTERIDINE DERIVATIVES |
摘要 |
<p>Title compds are formula (I), where R' and R2 are 1-4C alkyl or CR1R2 is a 4-6 membered spiralkyl gp., and are prepd. e.g. by (a) mild oxidation (O2 and I2/H+) of the corresp. 6-hydroxymethyl deriv. or (b) reductive cyclisation of a 2-amino 4-(1,1'-dialkyl-3'-hydroxyacetonyl )amino 6-hydroxy 5-nitro-pyrimidine oxime. (I) inhibits hydroxymethyldihydropteridine pyrophosphokinase, and compsns. with dihydrofolate reductase inhibitors and/or p-aminobenzoic acid competitors are synergistic.</p> |
申请公布号 |
CA1025855(A) |
申请公布日期 |
1978.02.07 |
申请号 |
CA19740191502 |
申请日期 |
1974.01.31 |
申请人 |
WELLCOME FOUNDATION LIMITED (THE) |
发明人 |
OHTA, KYUJI;WOOD, HAMISH C.S.;WHITTAKER, NORMAN;STIRLING, IRENE |
分类号 |
A61K31/505;A61K31/63;C07D475/04 |
主分类号 |
A61K31/505 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|