(2)-Aryl-(4)-arylamino-(6)-methyl-pyrimidines - useful as sedatives, antiulcer agents, anticholinergics, diuretics, analgesics etc.

摘要

2-Aryl-4-arylamino-6-methylpyrimidines of formula (I) are new: In the formula, (a) X is COR; Y is H; and (1) Ar is p-CIC6H4 and R is morpholino or piperidino; (2) Ar is o-CIC6H4 and R is morpholino; (3) Ar is m-FC6H4 and R is piperidino; (4) Ar is 3,4-OCH2OC6H3 or 3,4,5-(MeO)3-C6H2 and R is morpholino or NH2. Or (b) X is morpholinocarbonyl; Y is H or Me; and Ar is Ph opt. substd. by a halogen. Used as sedative, antiulcer, antibronchoconstrictive, anticholinergic, diuretic, analgesic, myorelaxant and anti-anoxemia agents. Dose: 100-3000 mg./day or orally.