发明名称 |
RECOMBINANT ANTI-TUMOR RNASE |
摘要 |
This invention provides for new recombinant ribonuclease proteins which are active when expressed by bacteria. This allows the recombinant ribonucleases of this invention to be fused in-frame with ligand binding moieties to form cytotoxic fusion proteins. Furthermore, these proteins are more active than ribonucleases currently available even though the proteins of this invention lack an N-terminal pyroglutamic acid, which has been found to be necessary for ribonucleolytic activity. Because these proteins are recombinant proteins, mutations which increase cytotoxicity can be engineered.
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申请公布号 |
CA2324646(A1) |
申请公布日期 |
1999.10.07 |
申请号 |
CA19992324646 |
申请日期 |
1999.03.26 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SEC RETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
NEWTON, DIANNE L.;RYBAK, SUSANNA M. |
分类号 |
A61K38/00;A61K47/48;C12N9/22;(IPC1-7):C12N15/52;A61K38/46;C12N15/62 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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