摘要 |
<p>Novel peptides, which are pharmaceutically useful, of the formula II <IMAGE> and the non-toxic salts thereof, are obtained by linking the individual amino acids to form a peptide intermediate of the formula III <IMAGE> in which the substituents are defined in claim 1, eliminating the protective group or the protective groups from the intermediate compound of the formula III, and, if X5 denotes a resin support, cleaving off the peptide from the resin and, where appropriate, preparing the non-toxic salts from resulting compounds. The peptides prepared in this way can be oxidised in order to form a disulphide bond between the said Cys residues. The novel peptides, which can be prepared in accordance with the invention, possess a specific effect in relation to stemming the release of insulin and glucagon in connection with the treatment of diabetes.</p> |