| 摘要 |
This invention relates to novel indolothiopyrones having the formula: <IMAGE> wherein R1 is hydrogen, lower alkyl or aryl; R2 is hydrogen or halogen; and R7 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, nitro-substituted-aryl, or omega -substituted lower alkyl wherein the substituent is: <IMAGE> wherein R4 and R5 each represent hydrogen, lower alkyl, or together with the nitrogen atom, form a heterocyclic ring; and R6 is lower alkoxy or amino, and novel intermediates used in their preparation. The indolothiopyrones are prepared by reacting a 3-mercaptoindole with sodium propiolate or a substituted sodium propiolate followed by acidification to obtain an intermediate acid; the intermediate acid cyclizes in the presence of an acid catalyst to obtain the indolothiopyrone structure which may be additionally subjected to halogenation, alkylation or hydrolysis to obtain derivatives having the various substituent groups disclosed. The compounds of this invention are useful in the treatment of angina pectoris and conditions benefiting from the depression of the central nervous system.
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