| 摘要 |
In the synthesis of penicillin antibiotics by silylation of the carboxyl and, where appropriate, of the amino group of 6-aminopenicillanic acid, acylation with an acid chloride or protected acid chloride and subsequent elimination of the silyl groups, the silylation stage is carried out in an inert solvent using a compound of the formula: R<1>R<2>N-COR<3> (I) or R<1>N=C(OR<2>)R<3> (II> and in this way improved. A compound of the formula: <IMAGE> is formed and is, without isolation, reacted with the acid chloride or protected acid chloride. The meaning of the symbols is given in Claim 1. |
