发明名称 Itraconazole analogs and use thereof
摘要 Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.
申请公布号 US9346791(B2) 申请公布日期 2016.05.24
申请号 US201214343040 申请日期 2012.09.07
申请人 The Johns Hopkins University 发明人 Liu Jun O.;Shi Wei;Pasunooti Kalyan Kumar
分类号 C07D405/14;A61K31/496;A61K31/506 主分类号 C07D405/14
代理机构 DLA Piper LLP (US) 代理人 DLA Piper LLP (US)
主权项 1. A compound of structural Formula (IV): or an optically pure stereoisomer or pharmaceutically acceptable salt thereof, wherein: A is CR6 or N; B is CR7 or N; W is CR8; V is CR9; each R2, R3, and R4 are independently chosen from the group consisting of alkoxy, alkyl, amino, halogen, hydroxyl, haloalkyl, perhaloalkyl, perhaloalkoxy, nitro, and cyano; R6, R7, R8, and R9 are each independently chosen from the group consisting of hydrogen, and halogen; p is an integer between 0 and 2; m is an integer between 0 and 4; q is 0; and R14 is chosen from the group consisting of hydrogen, alkyl, arylalkyl, alkoxyalkyl, arylalkoxy, alkynylalkyl, alkenylalkyl, cycloalkyl, cyanoalkyl, and cycloalkylalkyl, wherein at least one of A or B is N, and further wherein A and B are not both simultaneously N, wherein: each R5 is independently halogen; and t is 1 or 2.
地址 Baltimore MD US