4-IMIDAZOPYRIDAZIN-1-YL-BENZAMIDES AND 4-IMIDAZOTRIAZIN-1-YL-BENZAMIDES AS BTK-INHIBITORS
摘要
There are provided 6-5 membered fused pyridine ring compounds according to formula l (see formula I) or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and their possible use in therapy. The disclosure relates to the use of 6-5 membered fused pyridine ring compounds according to formula l for inhibiting Bruton's Tyrosine Kinase (Btk) in vitro which may allow the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.
申请公布号
CA2841886(C)
申请公布日期
2016.08.16
申请号
CA20122841886
申请日期
2012.07.11
申请人
MERCK SHARP & DOHME B.V.
发明人
BARF, TJEERD A.;JANS, CHRISTIAAN GERARDUS JOHANNES MARIA;MAN, DE ADRIANUS PETRUS ANTONIUS;OUBRIE, ARTHUR A.;RAAIJMAKERS, HANS C.A.;REWINKEL, JOHANNES BERNARDUS MARIA;STERRENBURG, JAN-GERARD;WIJKMANS, JACOBUS C.H.M.