发明名称 |
PROCEDE POUR LA PREPARATION DES ESTERS ASYMETRIQUES D'ACIDE 1,4-DIHYDROPYRIDIN-3,5-DICARBOXYLIQUE N-SUBSTITUE |
摘要 |
Unsymmetrical esters of N-substituted 4-substituted-1,4-dihydropyridine 3,5-dicarboxylic acid optionally substituted by lower alkyl groups in the 2- and 6-positions are cardiovascular agents. The compounds, of which 1,2,6-trimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine 3,5-dicarboxylic acid 3-methyl-5-ethyl ester is a typical example, can be prepared (A) through condensation of an ylidene- beta -ketocarboxylic acid ester, with a beta -ketocarboxylic acid ester and an amino or salt thereof, or with an enamino carboxylic acid ester or (B) through condensation of an aldehyde, an enamino carboxylic acid ester and a beta -ketocarboxylic acid ester. |
申请公布号 |
RO62798(A) |
申请公布日期 |
1977.11.15 |
申请号 |
RO19730073831 |
申请日期 |
1973.02.13 |
申请人 |
BAYER AG,DT |
发明人 |
MEYER,HORST,DT;BOSSERT,FRIEDERICH,DT;VATER,WULF,DT;STOEPEL,KURT,DT |
分类号 |
C07D211/84;A61K31/443;A61K31/4433;A61K31/455;A61P1/00;A61P3/06;A61P9/06;A61P9/08;A61P9/10;A61P9/12;A61P11/08;A61P13/02;A61P15/00;C07D211/90;C07D405/04;C07D409/04;(IPC1-7):07D211/82 |
主分类号 |
C07D211/84 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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