发明名称 |
PROCESS FOR THE PRODUCTION OF A STABLE INSULIN PREPARATION WITH PROTRACTED EFFECT |
摘要 |
<p>A stable insulin preparation having a lasting action and having low antigenicity is prepared by reaction of acidic groups of the insulin with basic groups of organic compounds. The reaction is carried out in an aqueous buffer solution which contains a protein-dissociating or protein-depolymerising agent. Basic polypeptides, e.g. protamines, or cleavage products of basic polypeptides are preferred as organic compounds containing a basic group. The protein-dissociating or protein-depolymerising agent is preferably urea.</p> |
申请公布号 |
GR58608(B) |
申请公布日期 |
1977.11.10 |
申请号 |
GR19347601497 |
申请日期 |
1976.01.07 |
申请人 |
NORDISK INSULINLABORATORIUM |
发明人 |
HANSEN B;ANDRESEN H |
分类号 |
C07K14/575;A61K9/00;A61K38/00;A61K38/28;A61K47/48;A61P43/00;C07K1/113;C07K14/62;C07K14/625;C07K16/00;C07K19/00;(IPC1-7):61K31/41 |
主分类号 |
C07K14/575 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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