Process for preparing pregn-20-yne compounds and novel product produced thereby

摘要

A process for preparing 17 beta -hydroxysteroido[2,3-d]isoxazoles substituted at the 17 alpha -position by an ethynyl or substituted ethynyl group comprising reacting a 17-oxosteroido[2,3-d]isoxazole with the appropriate ethynylmagnesium halide, substituted ethynylmagnesium halide, monolithium acetylide or substituted monolithium acetylide. The process affords a novel compound, 21-trifluoromethyl-17 alpha -pregn-4-en-20-yno[2,3-d]isoxazol-17-ol, which has estrogenic activity.