发明名称 |
UN METODO DE PREPARACION DE 1-(1-FENILETIL)-1H-IMIDAZOL-5- CARBOXILATO DE ALQUILO INFERIOR. |
摘要 |
<p>Optically active C1-C3-alkyl esters of 1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid are prepared by reacting racemic 1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid with an optically active isomer of 1-phenylethylamine, 1-(1-naphthyl)ethylamine or 1-(2-naphthyl)ethylamine. The resulting insoluble diastereomeric salt is separated off and treated with a strong non-oxidising mineral acid. The resulting optically active 1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid is then esterified with a C1-C3-alcohol. In another process, the resulting optically active acid is firstly converted into the acid halide and then correspondingly esterified. The prepared compounds can be used as hypnotics.</p> |
申请公布号 |
ES445450(A1) |
申请公布日期 |
1977.10.16 |
申请号 |
ES19500004454 |
申请日期 |
1976.02.23 |
申请人 |
JANSSEN PHARMACEUTICA, N. V. |
发明人 |
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分类号 |
C07D233/66;A61K31/4164;C07D233/90;(IPC1-7):07D/;61K/ |
主分类号 |
C07D233/66 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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