| 摘要 |
New derivatives of the formula: <IMAGE> (wherein X is O or NH; R1 is -OH which may optionally be etherified or esterified, etherified mercapto or -NH2 which may optionally be substituted; R2 and R3, respectively, mean H, lower alkyl or <IMAGE> and Y is an esterified or amidated carboxyl group, or CN). These derivatives are produced, by fluorination of corresponding 1,2,3,4-tetrahydro-2,4-dioxopyrimidine compounds and can be converted into 5-fluorouracil derivatives under hydrolytic conditions. The new derivatives are able to prolong the lives of animals having carcinomas or have antiviral activity. |
