| 摘要 |
Phenoxylakanols of the formula <IMAGE> wherein R1 is H or CH3; R2 is CH3 or C6H5; R3 is 4-Hal-phenoxymethyl, 1,2,3,4-tetrahydro-1-naphthyl, 1-pyrryl, piperidino, isoindoline, 1,2,3,4-tetrahydroquinoline, 1,2,3,4-tetrahydro-1-R5-4-quinolyl, 4-chromanyl, 4-thiochromanyl, or, when at least one of R1 and R2 is other than CH3, also Hal, phenyl, 4-Hal-phenyl or 4-Hal-phenoxy, wherein R4 is H or alkanoyl of 2-4 carbon atoms, R5 is H or CH3 and Hal if F, Cl or Br; and physiologically acceptable acid addition salts thereof possess pharmacological activity, particularly cholesterol, triglyceride and uric acid blood-level lowering activity and are also useful as intermediates for the production of the corresponding phenoxyacetic acids.
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