Intermediates for preparing cephalosporins

摘要

DELTA 3-Cephalosporins are prepared by reacting novel diorganodihalosilane or monorganodihalosilane derivatives of 7-aminocephalosporanic acid ("7ACA") and 7-amino-desacetoxycephalosporanic acid ("7ADCA") with known acylating agents followed by hydrolysis or alcoholysis to produce DELTA 3-cephalosporins with useful antibiotic activity. The dialkyldihalosilane derivatives are prepared by adding a base such as triethylamine slowly to a mixture of 7ACA or 7ADCA and a dialkyldihalosilane.