N-trifluoroacetyladriamycin-14-alkanoates and therapeutic compositions containing same

摘要

Esters of C4-C10 saturated fatty acids with N-trifluoroacetyladriamycin are novel compounds. These compounds have the following structure: in which A is alkanoate having from 4 to 10 carbon atoms. Therapeutic compositions containing these compounds or the acetate or propionate of N-trifluoroacetyladriamycin are more effective than adriamycin in antitumor activity against murine P 388 and L 1210 leukemias and Ridgway osteogenic sarcoma in mice and at the same time significantly less toxic than adriamycin.