| 摘要 |
<p>Title cpds. of formula (I):- (where R1 is H or lower alkyl and R2 is lower alkyl, or R1+R2 is -(CH2)1-5-; R3 is H or OH. R4 is H, Me or Et; and R5 is H or alkyl opt. substd. by a heterocyclic residue or is an aralkyl or aryloxyalkyl gp. in which the aryl moiety is opt. substd.), in the form of the racemates, diastereomeric racemates or optical antipodes, and their acid addn. salts, have peripheral vasodilatory activity and effects on blood pressure, and also increase cardiac efficiency (without increasing heart rate) and as broncholytic agents. (I) are also inters. for pharmaceuticals. They are pref. prepd. by removing the protecting gps. from a corresp. cpd. in which the omega-amino gp. is protected by a hydro(geno)lytically removable gp. and/or the phenolic OH gp. is protected by a gp. which is removable hydro(geno)lyticall, by re-esterificn. of by means of ether-eliminating agents.</p> |
