| 摘要 |
<p>Tetrahydropyridines of formula (I) (where R1 and R2 are H, alkyl, phenyl opt. substd by lower alkyl NO2, or halogen, or aralkyl or aralkenyl opt substd in aryl gp. by lower alkyl, NO2 or halogen), which are of use as intermediates for pharmaceuticals (e.g. the choleretic 2-hydroxyphenylacetic acid 4-methyl-1,3,5,6-tetrahydropyridide), are prepared by reacting a 1-benzyl-tetrahydro pyridine of formula (II): with a phenyl chlorocarbonate of formula (III) (where R3 and R4 are H, lower alkyl or halogen) at ca 20-140 degrees C, and saponifying the resulting phenoxycarbonyl-tetrahydropyridine (IV) in alkaline soln at ca 60-140 degrees C.</p> |
