| 摘要 |
Nontoxic sustained release pharmaceutical compositions containing one or more nonionic, lipophilic drugs in a cured low temperature vulcanizable (LTV) silicone elastomer excipient are prepared substantially free of toxic vulcanizing agents or drug-reactive by-products in the elastomeric material by curing with a vulcanizable composition comprising A. A POLYDIMETHYLSILOXANE HAVING VINYL GROUPS ON BOTH ENDS; B. A COPOLYMER CONSISTING ESSENTIALLY OF SiO2 units, (CH3)3SiO0.5 units, Vinyl(CH3)2SiO0.5 units; and C. A CROSS-LINKING Si-H component, consisting essentially of (CH3)3SiO0.5 units, (CH3)2SiO units, and CH3HSiO units. |
