发明名称 |
Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form. |
摘要 |
<p>A controlled release pharmaceutical composition in oral dosage unit form comprising a tablet comprising a therapeutically effective number of active spherical granules comprising an effective amount of active medicament, a pharmaceutically acceptable normally solid diluent adapted to form a diffusable matrix for the active medicament and an optional pharmaceutically acceptable excipient; and a number of compressible spherical granules comprising a mono- or di-saccharide, an optional pharmaceutical acceptable normally solid diluent adapted to form a diffusable matrix, an optional active medicament and/or an optional pharmaceutically acceptable excipient wherein the average compressive yield of the compressible spherical granules is less than the average compressive yield of the active spherical granules is provided. A method for the preparation and for the administration of the above defined composition is provided as well.</p> |
申请公布号 |
EP0418596(A2) |
申请公布日期 |
1991.03.27 |
申请号 |
EP19900116346 |
申请日期 |
1990.08.27 |
申请人 |
AMERICAN CYANAMID COMPANY |
发明人 |
DOYON, DANIEL JOSEPH;GANESAN, MADURAI GURUSAMY;PRESTON, WENDY ANN;SHETH, NITIN VADILAL |
分类号 |
A61K9/22;A61K9/20;A61K9/26;A61K9/52;B01J2/00;B01J2/20;B01J2/28 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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