| 摘要 |
<p>Mg salts of aryloxyalkanoc acids of formula (in which R1 is H, CL, Br or F; R2 is 1-3C alkyl; R3 is 1-3C alkyl) are prepd. by reacting metallic Mg with the corresp. acid in a solvent, pref. at 50-100 deg C. The resulting salts can be dehydrated at 90-150 deg C. These salts are used in medicine to diminish the formation of triglycinde-rich, very-low-density lipoproteins, tissue lipides and steroids (Mg salts are superior in this respect to esters of these acids which are susceptible to esterase). Mg activates enzymes in the main synthesis of aftty acids; diminishes the excitability of myocardium and reduces the toxicity of digitalis, and suppresses the formation of cholestin and accumulation of Ca in blood vessels walls. The use of metallic Mg instead of Mg salts employed in conventional processes simplifies the procedures as impurities are not introduced and pure Mg aryloxyalkanoates are obtd.</p> |
