SUBSTITUTED TETRALYLMETHYLEN-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS

摘要

Tetralylmethylen-2-oxindole derivatives having formula (I) wherein one or two of R, R1, R2 and R3 the said two being the same or different, are selected from: a) -X-(CH2)m-NH2, -X-(CH2)m-NR4R5 or -X-(CH2)m-NHR6 group, b) -NH-C(=NH)-NR4R5, -NH-C(=NH)-NHR6, -N=CH-NH2, -N=CH-NR4R5 or -N=CH-NHR6, c) -X-(CH2)n-COR7, d) -CORa or -COR8, e) -Y-CO-Y'-R9 group, f) -NHR6 or -NHR10 group and the pharmaceutically acceptable salts of the salt forming derivatives of formula (I) as defined above, are tyrosine kinase inhibitors.