| 摘要 |
1494462 Phenoxyphenyl-butyric acid derivatives MERCK PATENT GmbH 5 March 1976 [7 March 1975] 08980/76 Heading C2C Novel compounds I in which R<SP>1</SP> is H, C 1-6 alkyl or C n H 2n -R<SP>3</SP>, R<SP>2</SP> is H, Cl, Br or F, R<SP>3</SP> is di(C 1-4 alkyl)amino, pyrrolidino, piperidino, morpholino, piperazino, N-C 1-4 alkyl-piperazino or N-C 1-4 hydroxyalkyl-piperazino and n is 2, 3 or 4, and their physiologically acceptable salts, are prepared by reducing a compound II and R<SP>5</SP> is -C(CH 3 )R<SP>6</SP>-CH 2 -, -C(CH 3 )=CH-, -C(=CH 2 )-CH 2 -, -CH(CH 3 )-CHR<SP>7</SP>-, -(CH 3 )R<SP>6</SP>-CHR<SP>7</SP> or -C(CH 3 )=CR<SP>7</SP>, where R<SP>6</SP> and R<SP>7</SP> are each OH, Oacyl, SH, NH 2 , aralkyloxy or aralkylamino, followed, if desired, by treatment of a resulting compound I with a solvolysing, esterifying or salt-forming agent. Pharmaceutical compositions having antiinflammatory, analgesic, antipyretic, antiarteriosclerotic and thrombocyte aggregationinhibiting activity for oral, parenteral, rectal or topical administration, comprise one of the above novel compounds together with a pharmaceutically acceptable carrier. |
