PROCESS FOR THE GLYCOSYLATION OF AVERMECTIN COMPOUNDS

摘要

102/DLR52 18437 TITLE OF THE INVENTION A PROCESS FOR THE GLYCOSYLATION OF AVERMECTIN COMPOUNDS Avermectin compounds are glycosylated the 4' and 4"-positions by adding the avermectin compounds to the fermentation medium of Saccharapolyspora erythera. The outer oleandrose sugar group of the avermectin compound is glycosylated with a glycosyl moiety, specifically a glucose group. In addition, other changes are effected in the avermectin moiety such as selective hydroxylation, epimerization at the 2-carbon and migration of the .DELTA. 3-double bond to a .DELTA. 2-position.