发明名称 |
Antibodies to Plasminogen Activator Inhibitor-1 (PAI-1) and Uses Thereof |
摘要 |
The invention provides antibodies that specifically bind to Plasminogen Activator Inhibitor type-1 (PAI-1), The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-PAI-1 antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies to modulate PAI-1 activity or detect PAI-1, either in vitro or in vivo, are also provided. The disclosure further provides methods of making antibodies that specifically bind to PAI-1 in the active conformational state. |
申请公布号 |
US2016200831(A1) |
申请公布日期 |
2016.07.14 |
申请号 |
US201414911429 |
申请日期 |
2014.08.13 |
申请人 |
Sanofi |
发明人 |
Pritsker Alla;Grailhe Patrick;Rak Alexey;Mathieu Magali;Morgan Christopher Ryan;Baurin Nicolas;Poirer Bruno;Daveu Cyril;Duffieux Francis;Li Han;Kominos Dorothea;Janiak Philip |
分类号 |
C07K16/38 |
主分类号 |
C07K16/38 |
代理机构 |
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代理人 |
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主权项 |
1. An isolated monoclonal antibody that binds specifically to PAI-1, comprising:
(a) a heavy chain framework region and a heavy chain variable region, the heavy chain variable region comprising a heavy chain CDR1 region comprising SEQ ID NO: 34, a heavy chain CDR2 region comprising SEQ ID NO: 33, and a heavy chain CDR3 region comprising SEQ ID NO: 32; and (b) a light chain framework region and a light chain variable region, the light chain variable region comprising a light chain CDR1 region comprising SEQ ID NO: 37, a light chain CDR2 region comprising SEQ ID NO: 145, and a light chain CDR3 region comprising SEQ ID NO: 35. |
地址 |
Paris FR |