发明名称 |
ANTIBIRAL COMPOSITIONS CONTAINING PHORBOL DERIVATIVES AS THE MAIN ACTIVE INGREDIENT |
摘要 |
Antiviral compositions containing as the active ingredients: (i) phorbol derivatives which are represented by the general formula (I), have a ratio r=CC0/IC100 of 2 or more (wherein IC100 represents the concentration at which the cell pathogenic effect (CPE) of HIV-1 in MT-4 cells is inhibited at a ratio of 100%; and CC0 represents the concentration at which the survival of MT-4 cells is reduced in a cell proliferation test), and show activation of protein kinase C (PKC) at a concentration of 10 ng/mL of 30% or less; and (ii) a chemical capable of suppressing or inhibiting the replication process or the maturation process of viruses. In said formula (I), wherein R1, R2, R3, R4 and R5 independently represent each hydrogen, an aliphatic carboxylate or an aromatic carboxylate. These compositions are efficacious particularly against human immunodeficiency virus (HIV). |
申请公布号 |
WO0182927(A1) |
申请公布日期 |
2001.11.08 |
申请号 |
WO2000JP02913 |
申请日期 |
2000.05.02 |
申请人 |
LEAD CHEMICAL CO., LTD;HATTORI, MASAO;YAMAMOTO, NAOKI;MORI, MASAO |
发明人 |
HATTORI, MASAO;YAMAMOTO, NAOKI;MORI, MASAO |
分类号 |
A61K31/22;A61K31/23;A61K31/231;A61P31/18;C07C69/00;(IPC1-7):A61K31/22;A61K45/00;A61K31/122;A61K31/216 |
主分类号 |
A61K31/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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