| 摘要 |
The present invention concerns fusion of Fc domains with biologically active peptides and a process for preparing pharmaceutical agents using biologicall y active peptides. In this invention, pharmacologically active compounds are prepared by a process comprising: a) selecting at least one peptide that modulates the activity of a protein of interest; and b) preparing a pharmacologic agent comprising an Fc domain covalently linked to at least on e amino acid of the selected peptide. Linkage to the vehicle increases the hal f- life of the peptide, which otherwise would be quickly degraded in vivo. The preferred vehicle is an Fc domain. The peptide can be selected, for example, by phage display, E.coli display, ribosome display, RNA-peptide screening, yeast-based screening, chemical-peptide screening, rational design, or prote in structural analysis.
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